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Acambis, the vaccine manufacturer, is to be acquired by Sanofi-Aventis of France for £276m.
Acambis is to raise £40m in a share placing to fund the expansion of its vaccine manufacturing and research business, which includes sites in Cambridge and the US.
Acambis has sold Berna Products, the US-based distributor of oral typhoid vaccines with 15 staff, to Crucell for £9m.
Acambis has acquired a US-based 58,000 sq ft vaccine manufacturing facility in Rockville, MD, from BioReliance Corporation for £4m.
Acambis has secured a £28m capital injection from Baxter Healthcare to fund the refurbishment of a US plant to produce the smallpox vaccine.